A group on the Hannover Medical College, Clinic for Trauma Surgical procedure, led by Prof. Dr. med. Philipp Mommsen efficiently used a 3D-printed resorbable scaffold in critical-size massive segmental radius bone defect.
The scaffold was produced by medtech firm BellaSeno, which makes use of AM in its manufacturing course of. The corporate’s MDR-certified manufacturing platform is designed to fulfill the necessities of medical scaffolds starting from delicate tissue to bone and allows the manufacturing of each custom-made and off-the-shelf sterile medical implants.
The surgical procedure carried out by the healthcare professionals aimed to reconstruct a 14 cm segmental bone defect of the radial shaft after a third-degree open contaminated fracture attributable to traumatic gunshot damage.
Previous to his remedy at Hannover Medical College, the affected person had undergone eleven surgical procedures with delicate tissue and bony debridement to acquire secondary wound closure, whereas the radial fracture was solely stabilized by a hoop fixator. Following six additional operations and systemic antibiotic remedy to realize bacterial eradication of the surgical subject, bone reconstructive surgical procedure was carried out at Hannover Medical College utilizing BellaSeno’s resorbable scaffold along side an autologous bone graft from the medullary cavity of the femoral bone.
The scaffold is predicated on Resomer®, a biodegradable polymer platform developed by Evonik. The surgical procedure succeeded and after three months, the affected person confirmed well timed bony integration and had sufficient elbow operate with none indicators of wound therapeutic dysfunction. Additionally, no extra medical indicators of an infection had been obvious.
The scaffold was designed by BellaSeno as a custom-made cage to completely match the affected person’s anatomy and to make sure a safe maintain of autologous bone graft (RIA materials) within the massive void. To allow correct inside vascularization by the positioning of an arteriovenous loop or a central vascular pedicle throughout reconstructive surgical procedure sure design options had been included to permit the location of such a fragile construction contained in the scaffold.
To fabricate the scaffold, BellaSeno makes use of its proprietary AI-driven additive manufacturing services primarily based on a “no-touch method.” The cage consisting of an inside and outer help body with a fundamental and a locking half is created from utterly bioresorbable, high-quality, GMP-grade Resomer® polycaprolactone (mPCL) and offers osteoconductive properties.
Throughout surgical procedure, the group determined to make use of a vascular pedicle to make sure quick inside vascularization, which was positioned and stuck by way of an aperture positioned on the outer cage body. The process was carried out in October 2023.
“As the instance of the 46-year-old sufferers demonstrates, refined options to deal with massive bone defects are scarce. BellaSeno’s scaffold enabled us to conduct a brand new surgical approach for graft vascularization by embedding a vascular muscle arcade immediately right into a patient-specific, 3D-printed bioresorbable scaffold,” stated Prof. Dr. med. Philipp Mommsen, Managing Senior Doctor, Clinic for Trauma Surgical procedure at Hannover Medical College and lead creator of the paper. “This surgical process represents an modern and promising method for the restoration of in depth bone defects. As we see an growing variety of such catastrophic and really tough to deal with defects we face a quickly rising medical have to reconstruct such accidents.”
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